Manchester United hit a record low with their latest Premier League defeat to Brighton.

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Liverpool have agreed a British record transfer fee in the region of £110million for Moises Caicedo as the Reds look to shore up their midfield on the eve of the new season. The 21-year-old has been on Chelsea’s radar and the Blues – who will take on Liverpool in both sides’ Premier League opener on Sunday – were thought of as front-runners to sign the Ecuador international. But Brighton have held firm in their valuation of a player who joined them for just £4m from Ecuadorian side Independiente del Valle two years ago and now the Reds are now poised to sweep in. The PA news agency understands Liverpool, who are aiming to reinforce their options in the middle of the park following the departures of Jordan Henderson and Fabinho this summer, will pay upwards of the previous British record fee of £107m that Chelsea forked out for Enzo Fernandez in January. The fee for Caicedo dwarfs Liverpool’s own transfer record of £75m, which they paid Southampton for defender Virgil van Dijk in January 2018. Should Caicedo complete the move, he will be reunited with fellow midfielder Alexis Mac Allister, the Argentinian World Cup winner who left the Seagulls for Anfield in June. Liverpool have also signed Dominik Szoboszlai from RB Leipzig this summer after the departures of Henderson and Fabinho to Saudi Arabian clubs Al-Ettifaq and Al-Ittihad respectively. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live

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Sandro Tonali paid off the first instalment of his £52million transfer fee as he marked a fine debut with his first goal and inspired Newcastle to a 5-1 drubbing of Aston Villa. The 23-year-old Italy international opened the scoring just six minutes into his first competitive appearance for the Magpies and had a hand in two more of their goals as Alexander Isak helped himself to a double and substitutes Callum Wilson and Harvey Barnes struck late on after Moussa Diaby, also making his bow in England’s top flight, had levelled. However, a hugely entertaining game win was overshadowed by a potentially serious injury to Villa’s England defender Tyrone Mings, who was carried from the pitch on a stretcher to warm applause from a crowd of 52,207 at St James Park after going down following a clash with Isak. Neither Tonali nor Diaby wasted any time in making a significant impact for their new employers. Less than six minutes had elapsed when the Italian timed his arrival into the six-yard box perfectly to volley home Anthony Gordon’s cross after Emiliano Martinez had parried Bruno Guimaraes strike, and he might have doubled his tally two minutes later but for the goalkeeper’s block. However, Newcastle’s advantage lasted only fleetingly when Diaby, who had seen an earlier attempt from a tight angle saved by Nick Pope, was similarly well placed to equalise after Ollie Watkins had flicked on Lucas Digne’s left-wing cross. But the impressive Tonali was not finished and it was his deep 16th-minute cross which was turned acrobatically across goal by the stretching Sven Botman for Alexander Isak to open his account for the season from close range. Pope was relieved to see Watkins’ scuffed first-time effort from livewire Diaby’s pull-back after another menacing run slide just wide as an end-to-end encounter unfolded at frantic pace. Villa’s fortunes took a further turn for the worse when Mings, just days after midfielder Emiliano Buendia suffered a serious knee injury, was carried from the field following a tangle of legs with Isak. The visitors nevertheless refused to take a backwards step in a breathless contest and Watkins might have done better after meeting Digne’s corner unopposed, while Diaby fired into the side-netting from Luiz’s intelligent pass three minutes before the break. Martinez picked up a stoppage-time booking for hauling back Miguel Almiron outside his penalty area with the home crowd calling for a red card and making their feelings towards referee Andy Madley abundantly clear when he did not produce one. Another Villa new boy, Youri Tielemans, entered the fray as a half-time replacement for Leon Bailey, but Gordon saw a 51st-minute attempt deflected wide after Almiron had led a pacy counter-attack. Tielemans helped to drive the visitors forward once again, but that allowed the Magpies to exploit the space they left behind, and they went further ahead with 58 minutes gone when Isak pounced on a slip by Ezri Konsa before chipping the ball over the advancing Martinez. The Villa keeper had to race from his line once again to deny Joelinton, but recovered in time to field Almiron’s follow-up, although it was Pope who was called upon to repel Watkins’ 64th-minute drive before Matty Cash blazed over from the rebound. Martinez was beaten once again 13 minutes from time when Barnes collected Tonali’s pass and crossed for Wilson to score, and although the Argentina international denied Wilson a second with an instinctive save, he was beaten again by Barnes in added time. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Leigh hero Lachlan Lam reveals cup-winning drop-goal was step into unknown Rob Edwards admits Luton must make a rapid improvement after Brighton defeat Rangers boss Michael Beale pleased to end ‘rough week’ on high note with big win